Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

MURCS association


Other Names for this Disease
  • Klippel-feil deformity, conductive deafness, and absent vagina
  • Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview


MURCS association stands for (MU)llerian, (R)enal, (C)ervicothoracic (S)omite abnormalities and is a developmental disorder that primarily affects the reproductive and urinary systems.  Most individuals with MURCS association are female, although males can also have this condition.  Females with MURCS association can have an absent or abnormally shaped uterus. In rare cases, the vagina is also affected. Both males and females with MURCS association can have absent or abnormally formed reproductive tubes (usually the fallopian tubes in females and the vas deferens in males), kidney abnormalities, and short stature (adult height of less than 5 feet). [1][2] Additional symptoms might include fused spinal bones in the neck and upper back and hearing loss.[2] These symptoms may vary from person to person.  MURCS association is present at birth but may not be noticed until after puberty, especially when an affected female does not receive her first period.  This condition does not alter a person’s life expectancy.[1][2]
Last updated: 4/6/2011

References

  1. Duncan PA, Shapiro LR, Stangel JJ, Klein RM, Addonizio JC. The MURCS association: Mullerian duct aplasia, renal aplasia. J Pediatrics. 1979; 95(3):399. http://www.ncbi.nlm.nih.gov/pubmed/469663. Accessed 4/6/2011.
  2. Mahajan P, Kher A, Khungar A, Bhat M, Sanklecha M, Bharucha BA. MURCS association--a review of 7 cases. J Postgrad Med. 1992; 38:109. http://www.ncbi.nlm.nih.gov/pubmed/1303407. Accessed 4/6/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on MURCS association have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss MURCS association. Click on the link to view a sample search on this topic.