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Acquired Von Willebrand syndrome

Other Names for this Disease
  • Acquired Von Willebrand disease
  • Willebrand disease, acquired
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Acquired von Willebrand syndrome (AVWS) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a VWF gene mutation. It is most often seen in persons over age 40 years with no prior bleeding history. This condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid antibody syndrome), heart conditions such as aortic valvular stenosis, increased blood platelet count such as essential thrombocythemia, and certain drugs.[1] About 300 cases of this condition have been reported in the medical literature thus far. Treatment depends on the underlying cause of the condition.[2]
Last updated: 9/15/2011


  1. Goodeve A & James P. von Willebrand Disease. GeneReviews. October 2010; Accessed 9/15/2011.
  2. Acquired Von Willebrand syndrome. Orphanet. October 2008; Accessed 9/15/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Acquired Von Willebrand syndrome. This website is maintained by the National Library of Medicine.

In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Acquired Von Willebrand syndrome. Click on the link to view a sample search on this topic.