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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Prader-Willi syndrome


Other Names for this Disease
  • Prader-Labhart-Willi syndrome
  • PWS
  • Willi-Prader syndrome
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Your Question

Does the menstrual cycle happen earlier in Prader-Willi syndrome?

Our Answer

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Is puberty altered in individuals with Prader-Willi syndrome?

People with Prader-Willi syndrome (PWS) typically have hypogonadism, which can manifest as genital hypoplasia (underdevelopment), incomplete pubertal development, and infertility.[1] A small percentage of people with PWS may have early development of pubic hair; more rarely, precocious puberty (abnormally early onset of puberty, before the age of 8) has been reported.[2]
Last updated: 1/7/2015

Can the menstrual cycle happen early in people with Prader-Willi syndrome?

Many people with Prader-Willi syndrome (PWS) experience delayed puberty which fails to reach completion. Most females never have regular menstrual cycles, with spontaneous menarche occurring in only about 50% of cases.[1][3] Even in those who do experience menstruation, the cycles are often just a periodical vaginal spotting.[1] However, a few cases of precocious puberty with menarche at or before age 8 in people with PWS have been reported.[2][3]
Last updated: 1/7/2015

References
Other Names for this Disease
  • Prader-Labhart-Willi syndrome
  • PWS
  • Willi-Prader syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.