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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Idiopathic neutropenia

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* Not a rare disease
Other Names for this Disease
  • NI-CINA
  • Nonimmune chronic idiopathic neutropenia of adults
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Overview


Idiopathic neutropenia is an acquired form of severe chronic neutropenia whose cause is unknown.[1] Neutropenia is a blood condition that causes a reduced number or complete absence of neutrophils, a type of white blood cell that is responsible for much of the body's protection against infection. Symptoms include fever, moth sores, and other types of infections. Neutropenia idiopathic may occur in children and adults.[2] Frequency and severity of infections appear to be directly related to neutrophil count; while clinical problems in individual patients may vary, in general, those patients with more severe neutropenia have more frequent infections.[3] Most patients respond well to granulocyte-colony stimulating factor (G-CSF).[4] Long-term treatment is usually required.[2][3]  
Last updated: 1/13/2014

References

  1. Boxer, LA. Severe Combined Neutropenia. National Organization for Rare Disorders (NORD). 2012; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/857/viewAbstract. Accessed 1/13/2014.
  2. Types of neutropenia. National Neutropenia Network. 2014; http://www.neutropenianet.org/what-is-neutropenia/types-of-neutropenia/. Accessed 1/13/2014.
  3. Idiopathic Neutropenia. The Severe Chronic Neutropenia International Registry. http://depts.washington.edu/registry/Info.Idiopathic.Neut.htm. Accessed 1/13/2014.
  4. Treatment. National Neutropenia Network. 2014; http://www.neutropenianet.org/medical-care/treatment/. Accessed 1/13/2014.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Idiopathic neutropenia. Click on the link to view a sample search on this topic.