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Genetic and Rare Diseases Information Center (GARD)

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47, XYY syndrome


Other Names for this Disease
  • Jacobs syndrome
  • XYY Karyotype
  • XYY syndrome
  • YY syndrome
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Overview


47, XYY syndrome is characterized by an extra copy of the Y chromosome in each of a male's cells. Males with this condition typically do not have unusual physical features and usually have normal sexual development and are able to father children. Signs and symptoms vary widely among affected males and may include being taller than average; an increased risk of learning disabilities and delayed speech and language skills; delayed motor skills (such as sitting and walking); weak muscle tone (hypotonia); hand tremors or other involuntary movements (motor tics); and behavioral and emotional difficulties. A small percentage of males with 47, XYY syndrome are diagnosed with autism spectrum disorders. Most cases are not inherited.[1]
Last updated: 1/5/2012

References

  1. 47,XYY syndrome. Genetics Home Reference. January 2009; http://ghr.nlm.nih.gov/condition/47xyy-syndrome. Accessed 4/29/2011.
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Basic Information

In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss 47, XYY syndrome. Click on the link to view a sample search on this topic.