Albright's hereditary osteodystrophy
Other Names for this Disease
- Albright hereditary osteodystrophy
Your QuestionI was born with Albright's hereditary osteodystrophy. When I have children, is there a chance of them having it?
We have identified the following information that we hope you find helpful. If you still have questions, please contact us.
Questions on this page
- How is Albright's hereditary osteodystrophy (AHO) inherited?
- What is the chance that a woman with Albright's hereditary osteodystrophy (AHO) will have a child with the condition?
- What is the chance that a man with Albright's hereditary osteodystrophy (AHO) will have a child with this condition?
- How can I find a genetics professional in my area?
The GNAS gene has a complex genomic imprinting pattern. In some cells of the body the maternal copy of the gene is active, while in others the paternal copy is active. Hormone resistance and, in particular resistance to parathyroid hormone (PTH), depends on whether the mutated gene comes from the father or the mother. Within an extended family, some patients may have isolated features of AHO without hormone resistance (called pseudopseudohypoparathyroidism) and some may show the complete clinical picture.
Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.
The following online resources can help you find a genetics professional in your community:
- GeneTests has a searchable directory of US and international genetics and prenatal diagnosis clinics.
- The National Society of Genetic Counselors provides a searchable directory of US and international genetic counseling services.
- The American College of Medical Genetics has a searchable database of US genetics clinics.
- The University of Kansas Medical Center provides a list of US and international genetic centers, clinics, and departments.
- The American Society of Human Genetics maintains a database of its members, which includes individuals who live outside of the United States. Visit the link to obtain a list of the geneticists in your country, some of whom may be researchers that do not provide medical care.
- GNAS. Genetics Home Reference (GHR). January 2009; http://ghr.nlm.nih.gov/gene/GNAS. Accessed 10/17/2012.
- Carel JC, Kottler ML, Linglart A. Albright hereditary osteodystrophy. Orphanet. January 2004; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=665. Accessed 10/17/2012.