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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Alpers syndrome


Other Names for this Disease

  • Alpers diffuse degeneration of cerebral gray matter with hepatic cirrhosis
  • Alpers disease
  • Alpers progressive infantile poliodystrophy
  • Alpers-Huttenlocher syndrome
  • Diffuse cerebral degeneration in infancy
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Treatment

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How might Alpers syndrome be treated?

Treatment for Alpers syndrome is limited to managment of symptoms and supportive care. There is currently no cure. [1] [2]
A multi-disciplinary medical team of a gastroenterologist, neurologist, occupational, physical and/or speech therapist can assist with management of symptoms to maintain function as long as possible, insure comfort and promote the best possible quality-of-life. [1]
Last updated: 5/26/2011

References
  1. Cohen B, Chinnery P, Copeland W. POLG-Related Disorders. GeneReviews. March 16, 2010; http://www.ncbi.nlm.nih.gov/books/NBK26471/. Accessed 1/20/2011.
  2. Naviaux R K. Alpers syndrome. Orphanet. July 2006; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=726. Accessed 1/20/2011.
  3. NORD. Alpers Disease. NORD: National Organization for Rare Disease. 2007; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Alpers%20Disease. Accessed 1/20/2011.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • Orphanet lists clinical trials, research studies, and patient registries enrolling people with this condition. Click on Orphanet to view the list.
Other Names for this Disease
  • Alpers diffuse degeneration of cerebral gray matter with hepatic cirrhosis
  • Alpers disease
  • Alpers progressive infantile poliodystrophy
  • Alpers-Huttenlocher syndrome
  • Diffuse cerebral degeneration in infancy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.