Other Names for this Disease
- Antiphospholipid antibody syndrome
- Familial antiphospholipid syndrome
- Hughes syndrome
- Lupus anticoagulant, familial
Your QuestionCan you provide me with the latest figures for patients with antiphospholipid syndrome in the United States and in the United Kingdom, as well as the percentage of the world population affected by this condition?
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There are no hard and fast statistics about the number of people with antiphospholipid (aPL) antibodies or antiphospholipid syndrome (APS) in the United States (US). What we know is based on estimates from different studies over time. Research suggests that aPL antibodies may be found in around 1 to 5 percent of the healthy general population. This prevalence increases with age. Primary APS accounts for over 50% of cases. In individuals with systemic lupus erythematosus (SLE), approximately 30 percent have aPL antibodies, and around 30-50 percent of these individuals have symptoms and signs of APS. It is more difficult to measure the number of people with primary APS, but studies indicate that between 5-30 percent of individuals with thrombosis (blood clots) and no history of SLE have aPL antibodies. Additional studies suggest that aPL antibodies may play a role in approximately one-third of strokes in individuals under the age of 50.The international frequency of antiphospholopid syndrome is probably similar to the US frequency.
- Learning About Antiphospholipid Syndrome (APS). National Institute of Human Genome Research (NHGRI). February 25, 2009; http://www.genome.gov/17516396. Accessed 2/25/2009.
- Belilos E, Carsons S. Antiphospholipid Syndrome. eMedicine. August 10, 2007; http://emedicine.medscape.com/article/333221-overview. Accessed 2/25/2009.
- Tektonidou M. Orphanet Encyclopedia. May 2004; http://www.orpha.net/data/patho/Pro/en/Antiphospholipid-FRenPro5517.pdf. Accessed 2/25/2009.
- Antiphospholipid Antibody Syndrome: The Statistics. APS Foundation of America. October 2006; http://www.apsfa.org/aps.htm#4. Accessed 2/25/2009.