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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Antiphospholipid syndrome


Other Names for this Disease

  • Antiphospholipid antibody syndrome
  • APS
  • Familial antiphospholipid syndrome
  • Hughes syndrome
  • Lupus anticoagulant, familial
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

Can you provide me with the latest figures for patients with antiphospholipid syndrome in the United States and in the United Kingdom, as well as the percentage of the world population affected by this condition?


Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Can you tell me how many people are affected by antiphospholipid syndrome in the United States and the United Kingdom, as well as the percentage of the world population affected by this condition?

There are no hard and fast statistics about the number of people with antiphospholipid (aPL) antibodies or antiphospholipid syndrome (APS) in the United States (US). What we know is based on estimates from different studies over time.[1] Research suggests that aPL antibodies may be found in around 1 to 5 percent of the healthy general population.[1][2][3][4] This prevalence increases with age.[3] Primary APS accounts for over 50% of cases. In individuals with systemic lupus erythematosus (SLE), approximately 30 percent have aPL antibodies, and around 30-50 percent of these individuals have symptoms and signs of APS. It is more difficult to measure the number of people with primary APS, but studies indicate that between 5-30 percent of individuals with thrombosis (blood clots) and no history of SLE have aPL antibodies. Additional studies suggest that aPL antibodies may play a role in approximately one-third of strokes in individuals under the age of 50.[1]

The international frequency of antiphospholopid syndrome is probably similar to the US frequency.[2]
Last updated: 6/27/2011

Who can I contact to obtain additional statistical information about antiphospholipid syndrome?

The APS Foundation of America and the Hughes Syndrome Foundation (from the United Kingdom) can provide you with additional statistical information about antiphospholipid syndrome. Both of these groups are focused on better understanding the condition, who it affects, and how it can be managed.
Last updated: 6/27/2011

References
Other Names for this Disease
  • Antiphospholipid antibody syndrome
  • APS
  • Familial antiphospholipid syndrome
  • Hughes syndrome
  • Lupus anticoagulant, familial
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.