Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Calciphylaxis


Other Names for this Disease

  • Idiopathic calciphylaxis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs.  The lack of blood flow (ischemia) damages healthy tissue and causes it to die (necrosis).  The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can develop and become infected easily.  Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.  These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more than a few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure.[1]  The exact cause of calciphylaxis is unknown.[2]  Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition.[1]
Last updated: 2/7/2012

References

  1. Wilmer WA, Magro CM. Calciphylaxis: emerging concepts in prevention, diagnosis, and treatment. Seminars in Dialysis. 2002; 15:172-186. http://www.ncbi.nlm.nih.gov/pubmed?term=12100455. Accessed 2/2/2012.
  2. Nunley JR. Calciphylaxis. eMedicine. June 24, 2011; http://emedicine.medscape.com/article/1095481-overview#a0101. Accessed 2/2/2012.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Calciphylaxis have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Calciphylaxis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Idiopathic calciphylaxis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.