Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Iridocorneal endothelial syndrome


Other Names for this Disease

  • ICE syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

What is iridocorneal endothelial (ICE) syndrome?


What are the signs and symptoms of iridocorneal endothelial (ICE) syndrome?

What causes iridocorneal endothelial (ICE) syndrome?

How might iridocorneal endothelial (ICE) syndrome be treated?

What is iridocorneal endothelial (ICE) syndrome?

Iridocorneal endothelial (ICE) syndrome describes a group of eye diseases that are characterized by three main features:[1] 
  • Visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye) 
  • Swelling of the cornea, and 
  • The development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly)

ICE syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. The condition is actually a grouping of three closely linked conditions: Cogan-Reese syndrome; Chandler's syndrome; and essential (progressive) iris atrophy. The cause of ICE syndrome is unknown. While there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling.[1] 

Last updated: 12/1/2011

What are the signs and symptoms of iridocorneal endothelial (ICE) syndrome?

The most common feature of ICE syndrome is the movement of endothelial cells off the cornea onto the iris. This loss of cells from the cornea often leads to corneal swelling, distortion of the iris, and variable degrees of distortion of the pupil (the adjustable opening at the center of the iris that allows varying amounts of light to enter the eye). This cell movement also plugs the fluid outflow channels of the eye, causing glaucoma.[1]
Last updated: 12/1/2011

What causes iridocorneal endothelial (ICE) syndrome?

The cause of this disease is unknown.[1]
Last updated: 4/13/2010

How might iridocorneal endothelial (ICE) syndrome be treated?

While it is not possible to halt the progression of ICE syndrome, the glaucoma associated with the disease can be treated with medication, and a corneal transplant can treat the corneal swelling.[1]
Last updated: 4/13/2010

References
  1. Facts About The Cornea and Corneal Disease. National Eye Institute (NEI). May 2013; http://www.nei.nih.gov/health/cornealdisease/#g. Accessed 8/11/2014.


Other Names for this Disease
  • ICE syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.