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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Iridocorneal endothelial syndrome


Other Names for this Disease
  • ICE syndrome
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Overview


Iridocorneal endothelial (ICE) syndrome describes a group of eye diseases that are characterized by three main features:[1] 
  • Visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye) 
  • Swelling of the cornea, and 
  • The development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly)

ICE syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. The condition is actually a grouping of three closely linked conditions: Cogan-Reese syndrome; Chandler's syndrome; and essential (progressive) iris atrophy. The cause of ICE syndrome is unknown. While there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling.[1] 

Last updated: 12/1/2011

References

  1. Facts About The Cornea and Corneal Disease. National Eye Institute (NEI). 2010; http://www.nei.nih.gov/health/cornealdisease/#g. Accessed 12/1/2011.
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Basic Information

  • The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic. 

In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Iridocorneal endothelial syndrome. Click on the link to view a sample search on this topic.