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Genetic and Rare Diseases Information Center (GARD)

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Iridocorneal endothelial syndrome

Other Names for this Disease
  • ICE syndrome
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What are the signs and symptoms of iridocorneal endothelial (ICE) syndrome?

The most common feature of ICE syndrome is the movement of endothelial cells off the cornea onto the iris. This loss of cells from the cornea often leads to corneal swelling, distortion of the iris, and variable degrees of distortion of the pupil (the adjustable opening at the center of the iris that allows varying amounts of light to enter the eye). This cell movement also plugs the fluid outflow channels of the eye, causing glaucoma.[1]
Last updated: 12/1/2011

  1. Facts About The Cornea and Corneal Disease. National Eye Institute (NEI). 2010; Accessed 12/1/2011.