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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Chandler's syndrome


Other Names for this Disease

  • Chandler syndrome
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Treatment

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How might Chandler's syndrome be treated?

While it is not possible to halt the progression of Chandler's syndrome, the glaucoma associated with this disease can be treated with medications and/or filtering surgery.[1][2][3] Eye drops used in managing glaucoma decrease pressure in the eye by helping the eye's fluid drain more efficiently and/or decreasing the amount of fluid made by the eye.[4] Drugs used to treat glaucoma are classified according to their active ingredient. These include prostaglandin analogs, beta blockers, alpha agonists, and carbonic anhydrase inhibitors.[2258][4] Combination drugs may be necessary for some patients.[4] If these medications do not successfully treat the glaucoma, surgery may be indicated.[2258][4] Trabeculectomy may be used to treat glaucoma.[2258][5] In some cases, multiple procedures may be necessary.[5] The corneal swelling associated with Chandler's syndrome may be treated through a cornea transplant.[2258][1] Further investigation is needed to determine the best way to manage this condition.[6]
Last updated: 2/8/2012

References
  1. Facts About The Cornea and Corneal Disease. National Eye Institute (NEI). May 2013; http://www.nei.nih.gov/health/cornealdisease/#g. Accessed 8/11/2014.
  2. What is Irido Corneal Endothelial Syndrome (ICE)?. Glaucome Research Foundation. April 2011; http://www.glaucoma.org/q-a/what-is-irido-corneal-endothelial-syndrome-ice.php. Accessed 7/13/2011.
  3. Denis P. [Iridocorneal endothelial syndrome and glaucoma].. J Fr Ophtalmol. 2007; http://www.ncbi.nlm.nih.gov/pubmed/17318107. Accessed 7/13/2011.
  4. Glaucoma Care and Treatment Overview. Glaucoma Research Foundation. November 17, 2012; http://www.glaucoma.org/treatment/medication-guide.php. Accessed 2/7/2012.
  5. Doe EA, Budenz DL, Gedde SJ, et al.. Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome.. Ophthalmology. 2001; http://www.ncbi.nlm.nih.gov/pubmed/11581050. Accessed 7/13/2011.
  6. Morris RW, Dunbar MT. Atypical presentation and review of the ICE syndrome.. Optometry. 2004; http://www.ncbi.nlm.nih.gov/pubmed/14717277. Accessed 7/13/2011.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Chandler's syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Chandler syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.