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Chronic granulomatous disease


Other Names for this Disease
  • Granulomatous disease, chronic
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Overview


Chronic granulomatous disease (CGD) is a rare, inherited, primary immune deficiency disorder that affects certain white blood cells. It is characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Symptoms usually begin in infancy or childhood and include life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones; swollen areas of inflamed tissues known as granulomas; and other symptoms. It is caused by mutations in any one of four different genes and is usually inherited in an autosomal recessive or X-linked recessive manner. Treatment consists of continuous antibiotic therapy to help prevent infections and corticosteroid drugs for treating granulomatous complications.[1]
Last updated: 5/12/2011

References

  1. Granulomatous Disease, Chronic. NORD. January 14, 2009; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Granulomatous%20Disease%2C%20Chronic. Accessed 5/12/2011.
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Basic Information

  • The American Society of Gene & Cell Therapy provides information on the treatment of immunodeficiency diseases.
  • Genetics Home Reference (GHR) contains information on Chronic granulomatous disease. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
  • The National Institute of Allergy and Infectious Diseases (NIAID) supports scientists developing better ways to diagnose, treat, and prevent the many infectious, immunologic, and allergic diseases that afflict people worldwide. Click on the link to view information on this topic. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information