Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Chronic recurrent multifocal osteomyelitis

Other Names for this Disease
  • Chronic multifocal osteomyelitis
  • CMO
  • CRMO
  • Multifocal osteomyelitis, chronic
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


What is chronic recurrent multifocal osteomyelitis?

How might chronic recurrent multifocal osteomyelitis be treated?

What is chronic recurrent multifocal osteomyelitis?

Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory bone condition. Signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. Symptoms typically begin in childhood. CRMO may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, Majeed syndrome or DIRA. For most children, CRMO resolves after many years without lasting effects. However, CRMO can cause slow growth and permanent bone deformity.[1][2]
Last updated: 5/15/2013

How might chronic recurrent multifocal osteomyelitis be treated?

Due to the rare nature of the condition, there is limited data regarding the best treatment approach for people with chronic recurrent multifocal osteomyelitis (CRMO). When CRMO occurs along with  psoriasis or inflammatory bowel disease the goal is to treat both the CRMO as well as the skin and gastrointestinal symptoms. In this situation, treatment with a TNF inhibitor may be recommended. Initial treatment of isolated CRMO often involves NSAIDs. If NSAIDs are unable to control pain, additional treatment options include antirheumatic drugs (e.g., corticosteroids, methotrexate, sulfasalazine, colchicine, and azithromycin), TNF inhibitors, or bisphosphonates.[1]
Last updated: 5/15/2013

  1. Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep. 2012 Apr;14(2):130-41; Accessed 5/15/2013.
  2. Majeed syndrome. Genetics Home Reference. August 2009; Accessed 5/15/2013.