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Chronic recurrent multifocal osteomyelitis

Other Names for this Disease
  • Chronic multifocal osteomyelitis
  • CMO
  • CRMO
  • Multifocal osteomyelitis, chronic
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Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory bone condition. Signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. Symptoms typically begin in childhood. CRMO may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, Majeed syndrome or DIRA. For most children, CRMO resolves after many years without lasting effects. However, CRMO can cause slow growth and permanent bone deformity.[1][2]
Last updated: 5/15/2013


  1. Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep. 2012 Apr;14(2):130-41; Accessed 5/15/2013.
  2. Majeed syndrome. Genetics Home Reference. August 2009; Accessed 5/15/2013.
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