Other Names for this Disease
- Retinal telangiectasis
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The exact cause of Coats disease is not currently known. However, because it has been associated with different genetic syndromes, it has been thought to have a genetic component. It has been suggested that some cases of Coats disease may be due to somatic mutations in the NDP gene, which may result in the deficiency of a protein called norrin in the developing retina. A somatic mutation in this case is one that is acquired after an individual's conception (i.e. it was not inherited from a parent and cannot be passed on to an affected individual's children).
Last updated: 12/2/2011
- A. Del Longo. Coats disease. Orphanet. September 2004; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=190. Accessed 12/2/2011.
- Jane Kelly. Coats disease. OMIM. November 8, 2007; http://omim.org/entry/300216. Accessed 12/2/2011.