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Genetic and Rare Diseases Information Center (GARD)

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Cogan-Reese syndrome

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Cogan-Reese syndrome is an extremely rare eye disorder characterized by a matted or smudged appearance on the surface of the iris; the development of small colored lumps on the iris (nodular iris nevi); the attachment of portions of the iris to the cornea (peripheral anterior synechiae); and/or increased pressure in the eye (glaucoma). Secondary glaucoma may lead to vision loss. This disorder most frequently appears in young and middle-aged females, usually affecting only one eye and developing slowly over time. The cause of Cogan-Reese syndrome is unknown. Some researchers suspect that inflammation or chronic infection may be the cause. Others suggest that the cells that line the cornea (corneal endothelium) significantly impact the iris causing symptoms.[1] 
Last updated: 12/1/2011


  1. Cogan-Reese Syndrome. National Organization for Rare Disorders (NORD). 2003; Accessed 12/1/2011.
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Basic Information

  • The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Cogan-Reese syndrome. Click on the link to view a sample search on this topic.