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Genetic and Rare Diseases Information Center (GARD)

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Cold agglutinin disease

Other Names for this Disease
  • Anemia, hemolytic, cold antibody
  • CAD
  • Cold antibody disease
  • Cold antibody hemolytic anemia
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What causes cold agglutinin disease?

Although cold agglutinin disease is known to be an autoimmune disorder, its exact underlying cause is not fully understood. The underlying cause of the primary form is unknown (idiopathic). Secondary disease may be caused by infections (such as mycoplasma, Epstein-Barr virus, cytomegalovirus, mumps, varicella, rubella, adenovirus, HIV, influenza, hepatitis C, legionnare disease, syphilis, or listeriosi); other autoimmune diseases (such as systemic lupus erythematosus); or certain cancers (such as non-Hodgkin's lymphoma or chronic lymphocytic leukemia).[1][2][3]
Last updated: 12/13/2011

  1. Harper JL. Pediatric Cold agglutinin disease. eMedicine. August 2011; Accessed 1/20/2012.
  2. Georgy S. Cold agglutinin disease. eMedicine. November 2010; Accessed 1/20/2012.
  3. Cold antibody hemolytic anemia. National Organization for Rare Disorders (NORD). 2006; Accessed 1/20/2012.