Cold agglutinin disease
Other Names for this Disease
- Anemia, hemolytic, cold antibody
- Chronic cold agglutinin disease
- Cold agglutinin syndrome
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The exact underlying cause of cold agglutinin disease (CAD) is not fully understood. The underlying cause of the primary form is often unknown (idiopathic). Secondary CAD may be associated with infections (such as mycoplasma, Epstein-Barr virus, cytomegalovirus, mumps, varicella, rubella, adenovirus, HIV, influenza, hepatitis C, legionnare disease, syphilis, or listeriosi); other autoimmune diseases (such as systemic lupus erythematosus); or certain cancers (such as non-Hodgkin's lymphoma or chronic lymphocytic leukemia).
Last updated: 5/15/2014
- Harper JL. Pediatric Cold agglutinin disease. eMedicine. August 2011; http://emedicine.medscape.com/article/954954-overview. Accessed 1/20/2012.
- Georgy S. Cold agglutinin disease. eMedicine. November 2010; http://emedicine.medscape.com/article/135327-overview. Accessed 1/20/2012.
- Cold antibody hemolytic anemia. National Organization for Rare Disorders (NORD). 2006; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/723/viewAbstract. Accessed 1/20/2012.