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Genetic and Rare Diseases Information Center (GARD)

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Common variable immunodeficiency

Other Names for this Disease
  • Common variable hypogamma-globulinemia
  • CVID
  • Hypogamma-globulinemia, acquired
  • Immunoglobulin deficiency, late-onset
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How might common variable immunodeficiency be treated? 

Common variable immunodeficiency is caused by a lack of antibodies, also known as immunoglobulins.  The treatment is to "replace" antibodies into the body.  This treatment is called "immunoglobulin therapy", and it can be given in a vein (intravenously, IVIG) or under the skin (subcutaneously, SCIG).  This treatment is not a cure; individuals need to regularly receive this therapy to support their immune system. [1]
Last updated: 10/25/2010

  1. Frequently Asked Questions. Primary Immunodeficiency Resource Center. Accessed 10/12/2010.

Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Common variable immunodeficiency. Click on the link to go to to read descriptions of these studies.
  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, click on the link and enter the disease name in the "Terms Search" box. Then click "Submit Query".