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Common variable immunodeficiency
Other Names for this Disease
- Common variable hypogamma-globulinemia
- Hypogamma-globulinemia, acquired
- Immunoglobulin deficiency, late-onset
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antibodies in response to foreign substances that may cause infection. The main features that separate CVID from other immunodeficiencies are low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). Individuals with this condition develop more frequent infections, particularly in the sinuses, lungs, and digestive tract.   CVID symptoms most commonly begin in early adulthood, but have been found in children as young as two years. Though some cases of CVID are caused by known genetic factors, the cause of most cases is unknown.  CVID can sometimes be treated by "replacing" antibodies into the body; this treatment is called "immunoglobulin therapy". Common variable immunodeficiency is a group of disorders in which the immune system cannot make
Last updated: 10/25/2010
- Primary Immunodeficiency. National Institute of Child Health and Human Development (NICHD) . April 7, 2008; http://www.nichd.nih.gov/publications/pubs/primary_immuno.cfm#WhatisPrimaryImmunodeficiency. Accessed 10/12/2010.
- Schwartz RA, Modak RM, Modak P. Common Variable Immunodeficiency. eMedicine. March 16, 2010; http://emedicine.medscape.com/article/1051103-overview. Accessed 10/12/2010.
- Scharenberg, Andrew et al.. Common Variable Immune Deficiency Overview. GeneReviews. July 5, 2006; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cvid. Accessed 10/12/2010.
- Frequently Asked Questions. Primary Immunodeficiency Resource Center. http://www.info4pi.org/aboutPI/index.cfm?Section=aboutPI&content=faq&CFID=35047926&CFTOKEN=43348784#499. Accessed 10/12/2010.
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) provides information related to the health of children, adults, and families. Click on the link to view information on this topic.
- Genetics Home Reference (GHR) contains information on Common variable immunodeficiency. This website is maintained by the National Library of Medicine.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- The Immune Deficiency Foundation has an information page on this topic. Click on the link above to view the information page.
In Depth Information
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Common variable immunodeficiency. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Common variable immunodeficiency. Click on the link to view a sample search on this topic.