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Genetic and Rare Diseases Information Center (GARD)

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Cramp-fasciculation syndrome

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Your Question

Due to the rareness of cramp-fasciculation syndrome and because it is not fatal, there is very little information and research to be found online regarding this disease.  I am interested in any information, research studies, and treatments for this condition. There are only a few of us, but we all struggle with the lack of information and research regarding this disease.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is cramp-fasciculation syndrome?

Cramp-fasciculation syndrome is a rare condition of the muscles.  Individuals with this disease experience persistent muscle twitching (fasciculations) and cramping, which can lead to muscle discomfort, pain, or tiredness.  These symptoms are thought to be due to the overactivity of the associated nerves.  Muscles in the leg are most commonly affected, though this condition may involve several parts of the body.  Exercise often worsens symptoms.[1][2]  Cramp-fasciculation syndrome is believed to remain stable over time, meaning that it does not develop into a more serious disease.[2]
Last updated: 6/12/2013

What causes cramp-fasciculation syndrome?

Though the exact cause of cramp-fasciculation syndrome is unknown, one article in the medical literature suggests that this condition occurs because of nerve damage acquired over time.  The authors of this article also suggest that cramp-fasciculation syndrome may be a type of autoimmune disease.[3]
Last updated: 6/12/2013

  • Jansen PH, van Dijck JA, Verbeek AL, Durian FW, Joosten EM. Estimation of the frequency of the muscular pain-fasciculation syndrome and the muscular cramp-fasciculation syndrome in the adult population. European archives of psychiatry and clinical neuroscience. 1991; 241:102-104. Accessed 1/22/2013.
  • de Carvalho M, Swash M. Cramps, muscle pain, and fasciculations: not always benign?. Neurology. 2004; 63:721-723. Accessed 1/22/2013.
  • Hart IK, Maddison P, Newsom-Davis J, Vincent A, Mills KR. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain. 2002; 125:1887-1895. Accessed 1/22/2013.