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Other Names for this Disease
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mutations, certain metabolic diseases (such as rickets or an overactive thyroid) or can be associated with other disorders such as microcephaly and hydrocephalus. Treatment generally consists of surgery to improve the symmetry and appearance of the head and to relieve pressure on the brain and the cranial nerves.Craniosynostosis is a birth defect of the brain characterized by the premature closure of one or more of the joints between the bones of the skull (called the cranial sutures) before brain growth is complete. The first sign is an abnormally shaped skull; other features can include signs of increased intracranial pressure, developmental delays, intellectual disability, seizures, and blindness, caused by constriction of the growing brain. Closure of a single suture is most common and does not prevent the brain from expanding to a normal volume. When many sutures close prematurely, the skull cannot expand to accommodate the growing brain, leading to increased pressure and impaired development of the brain. Craniosynostosis can be caused by genetic
Last updated: 3/31/2011
- NINDS Craniosynostosis Information Page. NINDS. October 26, 2010; http://www.ninds.nih.gov/disorders/craniosynostosis/craniosynostosis.htm. Accessed 3/31/2011.
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- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
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- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss craniosynostosis. Click on the links below to go to some of the OMIM pages on this condition or visit OMIM and type "craniosynostosis" as your search term for a more expanded list of results.
Craniosynostosis, type 1 http://www.ncbi.nlm.nih.gov/omim/123100
Craniosynostosis, type 2 http://www.ncbi.nlm.nih.gov/omim/604757
Craniosynostosis, Adelaide type http://www.ncbi.nlm.nih.gov/omim/600593
Craniosynostosis, Philadelphia type http://www.ncbi.nlm.nih.gov/omim/601222
- PubMed is a searchable database of medical literature and lists journal articles that discuss Craniosynostosis. Click on the link to view a sample search on this topic.