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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Cushing's syndrome


Other Names for this Disease

  • Adrenal cortex adenoma
  • Adrenal hyperfunction resulting from pituitary acth excess
  • Cushing syndrome
  • Ectopic ACTH syndrome
  • Ectopic adrenocorticotropic hormone syndrome
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Cause

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What causes Cushing's syndrome?

Cushing's syndrome is caused by long-term exposure of the body's tissues to cortisol, a hormone that is naturally produced by the adrenal gland. Exposure to too much cortisol can result from long-term use of synthetic glucocorticoid hormones used to treat inflammatory illnesses. Excess levels of cortisol may also result from pituitary adenomas (benign tumors of the pituitary gland) which secrete increased amounts of adrenocorticotropic hormone or ACTH), a substance that controls the release of cortisol. Tumors of the adrenal gland or other areas of the body may also cause cortisol imbalances.[1]  
Last updated: 2/26/2013

References
  1. NINDS Cushing's Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). October 26, 2010; http://www.ninds.nih.gov/disorders/cushings/cushings.htm. Accessed 2/26/2013.


Other Names for this Disease
  • Adrenal cortex adenoma
  • Adrenal hyperfunction resulting from pituitary acth excess
  • Cushing syndrome
  • Ectopic ACTH syndrome
  • Ectopic adrenocorticotropic hormone syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.