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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Darier disease


Other Names for this Disease

  • Darier White Disease
  • Darier's disease
  • Keratosis follicularis
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Cause

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What causes Darier disease?

Darier disease is caused by mutations in the ATP2A2 gene. The linear form of Darier disease is caused by acquired somatic mutations that occur within the ATP2A2 gene; these mutations usually occur by chance and are not inherited from an affected parent. Various environmental factors may also contribute to flare-ups in affected individuals, especially during the summertime when there is increased exposure to heat and humidity. Flare-ups may also be caused by UV light exposure, friction, minor injuries, and certain medications.[1]
Last updated: 9/14/2011

References
  1. Darier disease. Genetics Home Reference. March 2008; http://ghr.nlm.nih.gov/condition=darierdisease. Accessed 3/6/2014.


Other Names for this Disease
  • Darier White Disease
  • Darier's disease
  • Keratosis follicularis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.