Other Names for this Disease
- Darier White Disease
- Darier's disease
- Keratosis follicularis
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Darier disease is caused by mutations in the ATP2A2 gene. The linear form of Darier disease is caused by acquired somatic mutations that occur within the ATP2A2 gene; these mutations usually occur by chance and are not inherited from an affected parent. Various environmental factors may also contribute to flare-ups in affected individuals, especially during the summertime when there is increased exposure to heat and humidity. Flare-ups may also be caused by UV light exposure, friction, minor injuries, and certain medications.
Last updated: 9/14/2011
- Darier disease. Genetics Home Reference. March 2008; http://ghr.nlm.nih.gov/condition=darierdisease. Accessed 3/6/2014.