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Genetic and Rare Diseases Information Center (GARD)

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Dubin-Johnson syndrome

Other Names for this Disease
  • Chronic Idiopathic Jaundice
  • Conjugated Hyperbilirubinemia
  • DJS
  • Hyperbilirubinemia 2
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Your Question

I have Dubin-Johnson syndrome. Can this condition be passed along to another individual through sexual intercourse?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is Dubin-Johnson syndrome?

Dubin-Johnson syndrome is a type of hereditary hyperbilirubinemia with a relatively benign course.[1] Symptoms may include a yellowish color to the skin (jaundice), and a liver that is sometimes enlarged and tender.[2]  The symptoms often do not present until puberty or adulthood. The syndrome interferes with the body's ability to move bilirubin from the liver. In most cases, treatment is not required.[3] 
Last updated: 12/19/2008

What causes Dubin-Johnson syndrome?

Dubin-Johnson syndrome is an autosomal recessive disorder that is caused by a mutation in the gene responsible for the human canalicular multispecific organic anion transporter (cMOAT) protein.[1] In order to inherit the condition, a child must get a copy of the defective gene from both parents.[3]
Last updated: 12/19/2008

Can Dubin-Johnsons syndrome be passed along to another individual through sexual intercourse?

No, Dubin-Johnson syndrome is caused by a mutated gene that is passed down through families, it is not a contagious condition and cannot be passed along to another individual through sexual intercourse. The gene that causes Dubin-Johnson syndrome (the human canalicular multispecific organic anion transporter (cMOAT) protein) can, however, be passed down to an affected individual's offspring.[1]
Last updated: 12/19/2008