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Duchenne muscular dystrophy
Other Names for this Disease
- Muscular dystrophy, Duchenne
- Muscular dystrophy, pseudohypertrophic progressive, Duchenne type
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Duchenne muscular dystrophy (DMD) is a rapidly progressive form of muscular dystrophy that occurs primarily in boys. It is caused by a mutation in a gene, called the DMD gene, which encodes the muscle protein dystrophin. Boys with Duchenne muscular dystrophy do not make the dystrophin protein in their muscles. Duchenne mucular dystrophy is inherited in an X-linked recessive fashion; however, it may also occur in people from families without a known family history of the condition. Individuals who have DMD have progressive loss of muscle function and weakness, which begins in the lower limbs. In addition to the skeletal muscles used for movement, DMD may also affect the muscles of the heart. There is no known cure for Duchenne muscular dystrophy. Treatment is aimed at control of symptoms to maximize the quality of life.
- Learning About Duchenne Muscular Dystrophy. National Human Genome Research Institute (NHGRI). http://www.genome.gov/19518854. Accessed January 8, 2009.
- Duchenne and Becker muscular dystrophy. Genetics Home Reference (GHR). http://www.ghr.nlm.nih.gov/condition/duchenne-and-becker-muscular-dystrophy. Accessed October 6, 2010.
- Kirmse B. Duchenne muscular dystrophy. MedlinePlus. http://www.nlm.nih.gov/medlineplus/ency/article/000705.htm. Accessed January 8, 2009.
- Genetics Home Reference (GHR) contains information on Duchenne muscular dystrophy. Click on the link to go to GHR and review the information.
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- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Duchenne muscular dystrophy. Click on the link to view a sample search on this topic.
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Duchenne muscular dystrophy. Click on the link to go to OMIM and review these resources.
Resources for Kids
- BrainPOP presents the topic of Duchenne muscular dystrophy in a short, animated movie that is available on CheckOrphan's Web site. BrainPOP produced this video in partnership with Parent Project Muscular Dystrophy, this four minute video strives to provide kids of all ages with a clear understanding of Duchenne.