Split hand foot malformation
- Lobster-claw deformity
- Split hand-split foot malformation
Your QuestionI have split hand foot malformation and would like to have children. Is there anything I can do to avoid the continuity of the syndrome?
We have identified the following information that we hope you find helpful. If you still have questions, please contact us.
Questions on this page
- What is split hand foot malformation?
- What causes split hand foot malformation?
- What are the chances that my future children will also have split hand foot malformation?
- Is there anything that can be done in order to avoid the continuity of this condition in my family?
- How might split hand foot malformation be treated?
More rarely other forms of inheritance have been reported (e.g., autosomal-recessive, X-linked, chromosome deletions, chromosome duplications).
PGD represents an alternative to prenatal diagnosis. It is used following in vitro fertilization to diagnose a genetic disease or condition in embryos. Only embryos that do not carry the disease-causing mutation are implanted in the mother's womb. PGD allows testing to occur before a pregnancy begins.
In many cases, the disease-causing mutation must be identified in an affected relative before PGD or prenatal diagnosis can be performed.
You can learn more about these and other tests by visiting the links below to the view information on this topic developed by the Centre for Genetic Education and by the Genetics and Public Policy Center:
Couples considering these options should talk with their healthcare provider and a genetic professional. It is important that couples are fully informed of the risks and benefits of each testing option and also have an opportunity to explore their feelings and beliefs regarding the use of these technologies. More information about genetic consultations is available from Genetics Home Reference at http://ghr.nlm.nih.gov/handbook/consult. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.
The following online resources can help you find a genetics professional in your community:
- GeneTests has a searchable directory of US and international genetics and prenatal diagnosis clinics.
- The National Society for Genetic Counselors provides a searchable directory of US and international genetic counseling services.
- The American College of Medical Genetics has a searchable database of US genetics clinics.
- The University of Kansas Medical Center provides a list of US and international genetic centers, clinics, and departments.
- The American Society of Human Genetics maintains a database of its members, which includes individuals who live outside of the United States. Visit the link to obtain a list of the geneticists in your country, some of whom may be researchers that do not provide medical care.
- Bianchi DW, Crombleholme T, D’Alton ME. Ectrodactyly. In: Bianchi DW et al.,. Fetology. Philadelphia, PA: McGraw-Hill; 2000;
- Duijf P, van Bokhoven H, Brunner HG. Pathogenesis of split-hand/split-foot malformation. Human Molecular Genetics. 2003;
- Elliott AM, Evans JA, Chudley AE. Split hand foot malformation. Clinical Genetics. December 2005; 68(6):501-5. http://www.ncbi.nlm.nih.gov/pubmed/16283879. Accessed 4/14/2011.
- Chorionic Villus Sampling (CVS). March of Dimes. 2007; http://tinyurl.com/lffsqs. Accessed 7/23/2009.
- Hanna KE. Reproductive genetic testing. National Human Genome Research Institute. 2006; http://www.genome.gov/10004766. Accessed 7/23/2009.
- Canale: Campbell's Operative Orthopaedics, 10th ed. Philadelphia, PA: Mosby, Inc; 2003;
- Ectrodactyly. Online Mendelian Inheritance in Man. 2004; http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=225300. Accessed 7/23/2009.