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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Ehlers-Danlos syndrome


Other Names for this Disease

  • ED syndrome
  • EDS
  • Ehlers Danlos syndrome
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Symptoms

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What are the signs and symptoms of Ehlers-Danlos syndrome?

There are six major types of Ehlers-Danlos syndrome (EDS) which are classified according to the signs and symptoms that are present.[1] Some individuals may be mildly affected, while others can have serious and potentially life-threatening complications.[2] Many of the findings associated with EDS are joint and skin related. Joint manifestations may include hypermobility and/or hyperextensibility (they move beyond the joint's normal range); loose or unstable joints which are prone to dislocations and/or subluxations (partial dislocations); joint pain; and early onset of osteoarthritis. Skin manifestations may include soft, "velvety" skin; skin hyperextensibility; fragile skin that tears or bruises easily; severe scarring; slow and poor wound healing; and development of molluscoid pseudo tumors (fleshy lesions associated with scars over pressure areas). Other signs and symptoms that can be associated with different types of EDS may include chronic, early onset, musculoskeletal pain (usually associated with the hypermobility type); arterial, intestinal, and/or uterine fragility or rupture (usually associated with the vascular type); scoliosis at birth and scleral fragility (associated with the kyphoscoliosis type); poor muscle tone (associated with the arthrochalasia type); mitral valve prolapse; and gum disease.[1]
Last updated: 3/5/2012

References
  1. What is EDS?. Ehlers-Danlos National Foundation. 2012; http://www.ednf.org/. Accessed 3/5/2012.
  2. Ehlers-Danlos syndrome. Genetics Home Reference. 2006; http://ghr.nlm.nih.gov/condition=ehlersdanlossyndrome. Accessed 7/21/2008.


Other Names for this Disease
  • ED syndrome
  • EDS
  • Ehlers Danlos syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.