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Genetic and Rare Diseases Information Center (GARD)

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Eosinophilic cystitis

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How might eosinophilic cystitis be treated?

Any possible causative factors, should be avoided or discontinued, such as certain medications (tranilast, mitomycin C). Non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin or ibuprofen, and antihistamines have been used as the primary management of choice with good results. Antibiotics are helpful, especially in those individuals with EC associated with urinary tract infections. Those who do not respond to NSAIDs and antihistamines have been treated with corticosteroids. Corticosteroids and antihistamines are used because they suppress the inflammatory reaction in the bladder.[1] However, symptoms of EC may persist, despite steroid therapy. If symptoms persist after steroid therapy, azathioprine or cyclosporine can be tried.[1] Other treatments include intravesical dimethylsulfoxide, cyclosporin-A (immunosuppressant drug), and silver nitrate.[2]

In those with bladder lesions, surgery has been successful. Few patients with progressive EC not responding to medical therapy or surgery may be considered for more radical procedures, such as partial/total cystectomy (surgical removal of all or part of the bladder).[2]
Last updated: 6/2/2011

  1. van den Ouden D. Diagnosis and management of eosinophilic cystitis: a pooled analysis of 135 cases. Eur Urol. 2000; 37(4):386-94. Accessed 6/2/2011.
  2. Teegavarapu PS, Sahai A, Chandra A, Dasgupta P, Khan MS. Eosinophilic cystitis and its management. Int J Clin Pract. 2005; 59(3):356-60. Accessed 6/2/2011.