Epidermolysis bullosa acquisita is a rare autoimmune disorder that causes the skin to blister in response to minor injury. Common areas of blistering include the hands, feet, knees, elbows, and buttocks. It can also affect the mouth, nose, and eyes. The blistering may cause scarring. Epidermolysis bullosa acquisita usually affects adults. Sometimes it occurs in association with other conditions such as Crohns disease and lupus.
Last updated: 10/21/2011
What causes epidermolysis bullosa acquisita?
Epidermolysis bullosa acquisita occurs when immune proteins (IgG autoantibodies) mistakenly target and attack a specific type of collagen (skin protein) involved in anchoring the skin. Occasionally it occurs in association with other autoimmune conditions, such as Crohns disease, lupus, amyloidosis, multiple myeloma, carcinoma of the lung, and lymphoma.
Last updated: 10/24/2011
How might epidermolysis bullosa acquisita be treated?
Due to the rarity of epidermolysis bullosa acquisita (EBA), data regarding the benefits of treatment is lacking. Treatments that have been tried, include systemic steroids, either alone or along with azathioprine, methotrexate, and cyclophosphamide, as well as intravenous immunoglobulin, rituximab and immunoadsorption. To learn more regarding your treatment options, please speak with a healthcare provider.