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Genetic and Rare Diseases Information Center (GARD)

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Erythromelalgia


Other Names for this Disease

  • Mitchell disease (formerly)
  • Primary erythermalgia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Erythromelalgia (EM) is a rare condition characterized by episodes of burning pain, warmth, swelling and redness in parts of the body, particularly the hands and feet. This condition may occur spontaneously (primary EM) or secondary to neurological diseases, autoimmune diseases, or myeloproliferative disorders (secondary EM). Episodes may be triggered by increased body temperature, alcohol, and eating spicy foods. About 15% of cases are caused by mutations in the SCN9A gene and are inherited in an autosomal dominant manner. Other cases may be caused by unidentified genes or by non-genetic factors. Treatment depends on the underlying cause and may include topical and/or oral medications. In some cases, the condition goes away without treatment.[1][2]
Last updated: 12/11/2013

References

  1. Erythromelalgia. DermNet NZ. July 1, 2011; http://dermnetnz.org/vascular/erythromelalgia.html. Accessed 12/11/2013.
  2. Erythromelalgia. Genetics Home Reference. November, 2012; http://ghr.nlm.nih.gov/condition=erythromelalgia. Accessed 12/11/2013.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

6 question(s) from the public on Erythromelalgia have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • Genetics Home Reference (GHR) contains information on Erythromelalgia. This website is maintained by the National Library of Medicine.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Erythromelalgia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Mitchell disease (formerly)
  • Primary erythermalgia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.