Factor V Leiden thrombophilia
* Not a rare disease
Other Names for this Disease
- APC resistance, Leiden type
- Hereditary resistance to activated protein C
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Your QuestionWondering if there is a connection between factor V Leiden and breast cancer? I have read that many people with breast cancer have factor V Leiden, but wondering which came first? I have asked many people and no one seems to have the answer.
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No. Factor V Leiden is the most common inherited form of thrombophilia. Between 3 and 8 percent of people with European ancestry carry one copy of the factor V Leiden mutation in each cell. Factor V Leiden and breast cancer are not known to be causally related; however, due to the high prevalence of mutations, it is quite possible for women with breast cancer to also have a mutation in factor V Leiden. In addition, testing for factor V Leiden (and other common genetic risk factors for thrombophilic events) may be ordered for breast cancer patients to assess risks for blood clots and stroke. For example, a number of studies have been done assessing the rate of tamoxifen-associated thrombophilic events in breast cancer patients with factor V Leiden mutations.
Last updated: 8/22/2013
- Factor V Leiden thrombophilia. Genetics Home Reference. August 2010; http://ghr.nlm.nih.gov/condition=factorvleidenthrombophilia. Accessed 8/8/2011.
- Mandalà M, Tondini C. Adjuvant therapy in breast cancer and venous thromboembolism. Thromb Res. 2012 Oct;130 Suppl 1:S66-70; http://www.ncbi.nlm.nih.gov/pubmed/23026668. Accessed 8/22/2013.