Factor V Leiden thrombophilia
* Not a rare disease
Other Names for this Disease
- APC resistance, Leiden type
- Hereditary resistance to activated protein C
Factor V Leiden increases the risk of developing a DVT during pregnancy by about seven-fold. Women with factor V Leiden who are planning pregnancy should discuss this with their obstetrician and/or hematologist. Most women with factor V Leiden have normal pregnancies and only require close follow-up during pregnancy. For those with a history of DVT or PE, treatment with an anticoagulant during a subsequent pregnancy can prevent recurrent problems. 
- Learning About Factor V Leiden Thrombophilia. National Human Genome Research Institute (NHGRI). December 2010; http://www.genome.gov/15015167. Accessed 3/18/2011.
- GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.