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Genetic and Rare Diseases Information Center (GARD)

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Familial Mediterranean fever


Other Names for this Disease
  • Benign paroxysmal peritonitis
  • Familial paroxysmal polyserositis
  • FMF
  • Periodic disease
  • Periodic fever
More Names
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Treatment


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How is familial Mediterranean fever (FMF) treated?

Currently, there is no known cure for FMF. Physicians can only treat the symptoms of the disease.[1]

A common therapy for FMF is daily use of the drug colchicine, a medicine that reduces inflammation. Colchicine is given orally, 1-2 mg/day in adults. Children may need 0.5-1 mg/day according to age and weight. Many people require colchicine for life.[2] This therapy has been successful in preventing attacks of fever in 75 percent of those who take the drug regularly. Over 90 percent of patients demonstrate a marked improvement. Even if colchicine does not prevent the fever attacks, it does prevent the amyloidosis. However, compliance in taking colchicine every day is very important. If a person stops taking the drug, an attack can occur within a few days.[1] Complications of colchicine use can also occur and include muscle weakness (myopathy) and a toxic epidermal necrolysis-like reaction.[2]

Since the gene that causes FMF codes for the protein pyrin, researchers hope that by studying how this protein works they will ultimately develop improved treatments for FMF, and possibly for other conditions involving excess inflammation.[1]
Last updated: 1/19/2012

References
  1. Learning about Familial Mediterranean Fever. NHGRI Web site. July 2010; http://www.genome.gov/12510679. Accessed 1/19/2012.
  2. Shohat M, Halpern GJ. Familial Mediterranean Fever. GeneReviews. April 2009; http://www.ncbi.nlm.nih.gov/books/NBK1227/. Accessed 1/19/2012.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Familial Mediterranean fever. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, click on the link and enter the disease name in the "Terms Search" box. Then click "Submit Query".

Medical Products

The medication(s) listed in the table(s) below have been approved by the Food and Drug Administration (FDA) for treatment of this condition. The FDA Office of Orphan Products Development designates "orphan products" for those that treat rare diseases affecting fewer than 200,000 Americans. The table(s) below may not be an exhaustive list of drugs or products used to treat this condition. There may be other products available that are not considered orphan products. To search for all FDA approved drugs, visit Drugs@FDA. You can find orphan products used to treat other conditions by searching the Orphan Drug Product Designation database.


Generic Name Colchicine
Trade Name
(Manufacturer Name)
Colcrys
(AR Holding Company, Inc.)
Indication
The FDA has approved this product to be used in this manner.
Treatment of Familial Mediterranean Fever
More Information about this product Drug Information Portal
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