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Genetic and Rare Diseases Information Center (GARD)

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Familial Mediterranean fever

Other Names for this Disease
  • Benign paroxysmal peritonitis
  • Familial paroxysmal polyserositis
  • FMF
  • Periodic disease
  • Periodic fever
More Names
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Your Question

Are there any precipitating factors for Familial Mediterranean Fever attacks?

Our Answer

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Are there any precipitating factors known to trigger Familial Mediterranean Fever attacks?

Although Familial Mediterranean Fever (FMF) is an autosomal recessive hereditary disease, environmental factors are also important in the triggering of attacks. Stress, fatigue, and infections may all play a role.[1]

In addition, a prodrome (pre-attack symptoms) is experienced by about 50% of persons with FMF. The prodrome recurs in most attacks, lasts an average of 20 hours, and manifests with either a mildly unpleasant sensation at the site of the forthcoming spell (discomfort prodrome), or with a spectrum of physical, emotional, and neuropsychological complaints (variant prodrome).[2]

Last updated: 8/5/2011