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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Familial Mediterranean fever


Other Names for this Disease

  • Benign paroxysmal peritonitis
  • Familial paroxysmal polyserositis
  • FMF
  • Periodic disease
  • Periodic fever
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

My son has been found to carry a single familial Mediterranean fever (FMF) gene mutation. Could he still have FMF?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Can a person have familial Mediterranean fever if they are found to carry only one gene mutation?

Yes. Although most people with familial Mediterranean fever (FMF) have two mutations in the MEFV gene, some people with FMF have only a single gene mutation identified by genetic testing. Individuals with one mutation tend to have milder symptoms than those with two mutations.[1]
Last updated: 6/29/2012

How can I find a genetics professional in my area?

Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.

The following online resources can help you find a genetics professional in your community:
Last updated: 6/5/2014

References
Other Names for this Disease
  • Benign paroxysmal peritonitis
  • Familial paroxysmal polyserositis
  • FMF
  • Periodic disease
  • Periodic fever
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.