Fatal familial insomnia
Other Names for this Disease
- Familial fatal insomnia
- Insomnia familial fatal
prion disease, also known as a transmissible spongiform encephalopathy (TSE). Prion diseases are progressive, neurodegenerative disorders that may affect humans and animals. The first symptoms of FFI usually begin in mid-life and may include insomnia that worsens over time and vivid dreams when sleep is achieved. These symptoms may be followed by high blood pressure; episodes of hyperventilation; excessive tearing; and/or sexual and urinary tract dysfunction. Other nervous system abnormalities then follow, and affected people develop ataxia (loss of muscle control) over a period of months. FFI usually leads to death within a few months to a few years. Genetic prion diseases are inherited in an autosomal dominant manner and may be caused by mutations in the PRNP gene. Treatment aims at alleviating symptoms when possible.Fatal familial insomnia (FFI) is a type of genetic
Last updated: 7/3/2014
- Fatal Familial Insomnia. Online Mendelian Inheritance in Man (OMIM). 2010; http://www.ncbi.nlm.nih.gov/omim/600072. Accessed 7/26/2010.
- Prion disease. Genetics Home Reference (GHR). 2007; http://ghr.nlm.nih.gov/condition/prion-disease. Accessed 7/26/2010.
- James A Mastrianni. Genetic Prion Diseases. GeneReviews. January 2, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1229/. Accessed 7/3/2014.
- Genetics Home Reference (GHR) contains information on Fatal familial insomnia. This website is maintained by the National Library of Medicine.
- The Merck Manual provides information on this condition for patients and caregivers.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Fatal familial insomnia. Click on the link to view a sample search on this topic.
- The Social Security Administration has included this condition in their Compassionate Allowances Initiative. This initiative speeds up the processing of disability claims for applicants with certain medical conditions that cause severe disability. More information about Compassionate Allowances and applying for Social Security disability is available online.