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Fatal familial insomnia

Other Names for this Disease
  • Familial fatal insomnia
  • Insomnia familial fatal
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Fatal familial insomnia is a prion disorder showing autosomal dominant inheritance.[1] Prion diseases belong to group of progressive conditions that affect the nervous system in humans and animals.[2] Fatal familial insomnia is characterized by insomnia with or without a diurnal dreaming state, hallucinations, delirium, and dysautonomia preceding motor and cognitive deterioration.[1]. To date, there is no treatment of the underlying pathological mechanisms of the disease.[3] The signs and symptoms typically begin in adulthood and lead to death within 6 to 32 months.[2][3]
Last updated: 7/26/2010


  1. Fatal Familial Insomnia. Online Mendelian Inheritance in Man (OMIM). 2010; Accessed 7/26/2010.
  2. Prion disease. Genetics Home Reference (GHR). 2007; Accessed 7/26/2010.
  3. Brande JP. Fatal familial insomnia. Orphanet. August 2004; Accessed 7/26/2010.
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  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Fatal familial insomnia. Click on the link to view a sample search on this topic.

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