Other Names for this Disease
- Fibrous dysplasia of bone
- Osteofibrous dysplasia
Your QuestionI am interested in reading the most up-to-date research on the use of bisphosphonate therapy in treating adult PFD. What I have found in my search so far is that while it does seem to treat pain associated with PFD, it doesn't actually stop the progression of the condition. Also, I understand that long-term (over 3 years) use of bisphosphonates actually makes bones subject to fracture. So I was just looking for some answers.
We have identified the following information that we hope you find helpful. If you still have questions, please contact us.
Questions on this page
So far studies investigating the use of bisphosphonate therapies for treatment of fibrous dysplasia have been small and uncontrolled. Further information regarding the benefits and complications associated with bisphosphonate therapy for treatment of fibrous dysplasia is likely on the horizon. The National Institute of Dental and Craniofacial Research at the National Institutes of Health completed a three year, phase 2, clinical trial of Fosamax (Alendronate) for treatment of fibrous dysplasia. The clinical trial was entitled 'Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome.' Click here to view the study information. In our search, we were unable to find published results from the trial. You can contact the National Library of Medicine (NLM) Customer Service for further assistance in searching the medical literature for published results.
National Library of Medicine Customer Service
In addition, there is an ongoing clinical trial in Europe, entitled Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone (PROFIDYS), that is investigating the efficacy of oral bisphosphonate to decrease bone pain and improve radiological appearance of fibrous dysplasia. Click on the title above to learn more.
- Silverman SL. Bisphosphonate use in conditions other than osteoporosis. Annals of the New York Academy of Sciences. 2011; 1218:33-37. http://www.ncbi.nlm.nih.gov/pubmed/20946575. Accessed 8/23/2011.