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Fibrous dysplasia


Other Names for this Disease
  • Fibrous dysplasia of bone
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Overview


Fibrous dysplasia is a progressive bone disorder that is characterized by the replacement of normal bone with weaker tissues, such as fibrous tissue and woven bone.  It may involve one bone (monostotic) or multiple bones (polyostotic).[1]  Though many individuals with this condition do not have any symptoms, others may have bone pain, abnormally shaped bones, or an increased risk of breaking bones.[2]  This condition can occur alone or as part of a genetic disorder, such as McCune-Albright syndrome.[1][3][4]
Last updated: 8/25/2011

References

  1. Merchant SN, Nadol JB Jr. Otologic manifestations of systemic disease. In: Cummings CW et al., eds. Otolaryngology: Head & Neck Surgery, 4th ed. Philadelphia, PA: Mosby, Inc; 2005;
  2. Chapurlat RD, Meunier PJ. Fibrous dysplasia of the bone. Bailliere's Best Practices & Research. Clinical Rheumatology. 2000; 14:385-398. http://www.ncbi.nlm.nih.gov/pubmed/10925751. Accessed 8/23/2011.
  3. Rosenberg AE. Bones, joints, and soft tissue tumors. In: Kumar V et al., eds. Pathologic Basis of Disease, 7th ed. Philadelphia PA: Saunders; 2005;
  4. Feske SK, Cochrane TI. Degenerative and compressive structural disorders. In: Goetz CG. Textbook of Clinical Neurology, 3rd ed. Philadelphia PA: Sunders; 2007;
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Basic Information

  • The Children's Hospital Boston's Web site has an information page on this topic. Click on the link above to view this information page.
  • The MayoClinic.com Web site has an information page on fibrous dysplasia. Click on MayoClinic.com to view the information page.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
  • The Osteoporosis and Related Bone Diseases ~ National Resource Center provides patients, health professionals, and the public with an important link to resources and information on metabolic bone diseases, including osteoporosis, Paget's disease of the bone, osteogenesis imperfecta, and hyperparathyroidism. Contact them directly by calling toll-free at 800-624-2663 or by e-mail at NIAMSBoneInfo@mail.nih.gov

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Fibrous dysplasia. Click on the link to view a sample search on this topic.