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Fibrodysplasia ossificans progressiva
Other Names for this Disease
- FOP
- Myositis ossificans
- Myositis ossificans progressiva
- Progressive myositis ossificans
- Progressive ossifying myositis
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Overview
Fibrodysplasia ossificans progressiva (FOP) is a disorder in which muscle and connective tissue, such as tendons and ligaments, are gradually replaced by bone (ossified). This condition leads to bone formation outside the skeleton (extra-skeletal or heterotopic bone) which constrains movement. This process generally becomes noticeable in early childhood, starting with the neck and shoulders and moving down the body and into the limbs. People with FOP are generally born with abnormally big toes which can be helpful in clarifying the diagnosis.[1]
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Trauma to the muscles of an individual with FOP, such as a fall or invasive medical procedure, or a viral illness may trigger episodes of muscle swelling and inflammation (myositis) followed by more rapid bone growth in the injured area.[1]
FOP can be caused by mutations in the ACVR1 gene and is inherited in an autosomal dominant manner.[1]References
- Fibrodysplasia ossificans progressiva. Genetic Home Reference. http://ghr.nlm.nih.gov/condition/fibrodysplasia-ossificans-progressiva. Accessed March 16, 2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center1 question(s) from the public on Fibrodysplasia ossificans progressiva have been answered. See questions and answers. You can also submit a new question.
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General Information
- Genetics Home Reference (GHR) contains information on Fibrodysplasia ossificans progressiva. Click on the link to go to GHR and review the information.
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The National Center for Biotechnology Information (NCBI) was established in 1988 as a national resource for molecular biology information. Click on the link to view information on this topic.
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Click on the link to read information on this topic.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Fibrodysplasia ossificans progressiva. Click on the link to view a sample search on this topic.
- The The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Fibrodysplasia ossificans progressiva. Click on the link to go to OMIM and review these resources.
Basic Information
- Support guidebooks published by the International Fibrodysplasia Ossificans Progressiva Association contains information about research and treatment options, as well as articles by parents of affected children and adults with FOP offering insights into the condition.
Insurance Issues
- The Social Security Administration has included this condition in their Compassionate Allowances Initiative. This initiative speeds up the processing of disability claims for applicants with certain medical conditions that cause severe disability. More information about Compassionate Allowances and applying for Social Security disability is available online.