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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Trimethylaminuria


Other Names for this Disease
  • Fish malodor syndrome
  • Fish odor syndrome
  • Stale fish syndrome
  • TMAU
  • TMAuria
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Inheritance

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How is trimethylaminuria inherited?

Trimethylaminuria is usually inherited in an autosomal recessive manner.[1] This means that to be affected, a person must have a mutation in both copies of the responsible gene in each cell. The parents of an affected person usually each carry one mutated copy of the gene and are referred to as carriers. Carriers typically do not show signs or symptoms of the condition, although carriers of trimethylaminuria may experience mild symptoms or have temporary episodes of fish-like odor.[2] When two carriers of an autosomal recessive condition have children, each child has a 25% (1 in 4) risk to have the condition, a 50% (1 in 2) risk to be a carrier like each of the parents, and a 25% chance to not have the condition and not be a carrier.
Last updated: 3/27/2015

References
  1. Trimethylaminuria. Genetics Home Reference. January 2013; http://ghr.nlm.nih.gov/condition=trimethylaminuria.
  2. Learning about Trimethylaminuria. National Human Genome Research Institute. July 2011; http://www.genome.gov/11508983.


Other Names for this Disease
  • Fish malodor syndrome
  • Fish odor syndrome
  • Stale fish syndrome
  • TMAU
  • TMAuria
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.