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Genetic and Rare Diseases Information Center (GARD)

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Diffuse idiopathic skeletal hyperostosis


* Not a rare disease
Other Names for this Disease
  • Ankylosing vertebral hyperostosis with tylosis
  • DISH
  • DISH Forestier's disease
  • Forestier disease
  • Forestier-Rotes disease
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What causes diffuse idiopathic skeletal hyperostosis (DISH)?

The cause of diffuse idiopathic skeletal hyperostosis remains unknown, but several risk factors are implicated on the basis of its frequent association with various metabolic conditions, including hyperinsulinemia with or without diabetes mellitus (perhaps due to insulin or insulin-like growth factors that promote new bone growth), obesity, hyperuricemia, dyslipidemia, hypertension, and the prolonged use of isoretinol. Age (being older than age 50) and sex (being male) also play a role.[1][2]
Last updated: 11/14/2013

  1. Diffuse Idiopathic Skeletal Hyperostosis (DISH). The Arthritis Society. 2013; Accessed 11/14/2013.
  2. Diffuse idiopathic skeletal hyperostosis (DISH). Mayo Foundation for Medical Education and Research. November 2, 2012; Accessed 11/17/2013.