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Genetic and Rare Diseases Information Center (GARD)

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Gardner syndrome


Other Names for this Disease

  • Gardner's syndrome
  • Intestinal polyposis, osteomas, sebaceous cysts
  • Polyposis coli and multiple hard and soft tissue tumors
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Overview

Gardner syndrome is a form of familial adenomatous polyposis (FAP) that is characterized by multiple colorectal polyps and various types of tumors, both benign (noncancerous) and malignant (cancerous). People affected by Gardner syndrome have a high risk of developing colorectal cancer at an early age. They are also at an increased risk of developing other FAP-related cancers, such as those of the small bowel, stomach, pancreas, thyroid, central nervous system, liver, bile ducts, and/or adrenal gland. Other signs and symptoms of Gardner syndrome include dental abnormalities; osteomas (benign bone growths); various skin abnormalities such as epidermoid cysts, fibromas (a benign tumor of the connective tissue), and lipomas; and desmoid tumors. It is caused by changes (mutations) in the APC gene and inherited in an autosomal dominant manner. Although there is no cure for Gardner syndrome, management options are available to reduce the risk of cancer. These may include high risk screening, prophylactic surgeries and/or certain types of medications.[1][2][3]
Last updated: 1/14/2015

References

  1. Hemant Singhal, MD, MBBS, FRCSEd, FRCS(C). Gardner syndrome. Medscape Reference. June 2014; http://emedicine.medscape.com/article/190486-overview.
  2. Randall W Burt, MD. Gardner syndrome. UpToDate. January 2015; Accessed 1/14/2015.
  3. Kory W Jasperson, MS and Randall W Burt, MD. APC-Associated Polyposis Conditions. GeneReviews. March 27, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1345/.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

3 question(s) from the public on Gardner syndrome have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • Cancer.Net, oncologist-approved cancer information from the American Society of Clinical Oncology, has information about Gardner syndrome. Click on the link to view the information.
  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • Genetics Home Reference (GHR) contains information on Gardner syndrome. This website is maintained by the National Library of Medicine.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
    Gardner syndrome
    Dermatologic Manifestations of Gardner Syndrome
    Pediatric Gardner Syndrome
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Gardner syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Gardner's syndrome
  • Intestinal polyposis, osteomas, sebaceous cysts
  • Polyposis coli and multiple hard and soft tissue tumors
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.