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Genetic and Rare Diseases Information Center (GARD)

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Focal segmental glomerulosclerosis


Other Names for this Disease

  • Focal sclerosis with hyalinosis
  • Focal segmental glomerulosclerosis 1
  • FSGS
  • FSGS1
  • Glomerulosclerosis, focal
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Overview

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney.[1] FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling.[2][3] In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).[3]  The goal of treatment is to control symptoms and prevent chronic kidney failure.[1] Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.[1]
Last updated: 8/16/2011

References

  1. Focal segmental glomerulosclerosis. MedlinePlus. http://www.nlm.nih.gov/medlineplus/ency/article/000478.htm. Accessed 8/16/2011.
  2. Glomerular diseases. National Kidney & Urologic Diseases Information Clearinghouse. September 2, 2010; http://kidney.niddk.nih.gov/kudiseases/pubs/glomerular/. Accessed 8/16/2011.
  3. Focal segmental glomerulosclerosis (FSGS). UNC Kidney Center Web site. http://www.unckidneycenter.org/kidneyhealthlibrary/fsgs.html. Accessed 8/16/2011.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), conducts and supports research on a broad spectrum of diseases affecting public health. Click on the link to view information on this topic.

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  • The Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Focal segmental glomerulosclerosis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Focal sclerosis with hyalinosis
  • Focal segmental glomerulosclerosis 1
  • FSGS
  • FSGS1
  • Glomerulosclerosis, focal
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.