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Glucose-6-phosphate dehydrogenase deficiency


Other Names for this Disease

  • G6PD deficiency
  • Hemolytic anemia due to G6PD deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Glucose 6 phosphate dehydrogenase (G6PD) deficiency is a hereditary condition in which red blood cells break down (hemolysis) when the body is exposed to certain foods, drugs, infections or stress. This condition occurs when a person is missing or doesn't have enough glucose-6-phosphate dehydrogenase, an enzyme which helps red blood cells work properly.[1][2] G6PD deficiency is more likely to occur in males, particularly African Americans, and those from certain parts of Africa, Asia, and the Mediterranean. This condition is inherited in an X-linked recessive manner and is caused by mutations in the G6PD gene.[1]
Last updated: 10/11/2011

References

  1. Dugdale DC, Mason JR. Glucose-6-phosphate dehydrogenase deficiency . MedlinePlus. March 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000528.htm. Accessed 10/11/2011.
  2. Glucose-6-phosphate dehydrogenase deficiency. Genetics Home Reference (GHR). May 2006; http://www.ghr.nlm.nih.gov/condition/glucose-6-phosphate-dehydrogenase-deficiency. Accessed 10/11/2011.
Your Questions Answered
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Basic Information

  • Genetics Home Reference (GHR) contains information on Glucose-6-phosphate dehydrogenase deficiency. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Heart, Lung, and Blood Institute (NHLBI) provides leadership for a national program in diseases of the heart, blood vessels, lung, and blood; blood resources; and sleep disorders. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Glucose-6-phosphate dehydrogenase deficiency. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • G6PD deficiency
  • Hemolytic anemia due to G6PD deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.