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Glucose-6-phosphate dehydrogenase deficiency

Other Names for this Disease
  • G6PD deficiency
  • Hemolytic anemia due to G6PD deficiency
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Glucose 6 phosphate dehydrogenase (G6PD) deficiency is a hereditary condition in which red blood cells break down (hemolysis) when the body is exposed to certain foods, drugs, infections or stress. This condition occurs when a person is missing or doesn't have enough glucose-6-phosphate dehydrogenase, an enzyme which helps red blood cells work properly.[1][2] G6PD deficiency is more likely to occur in males, particularly African Americans, and those from certain parts of Africa, Asia, and the Mediterranean. This condition is inherited in an X-linked recessive manner and is caused by mutations in the G6PD gene.[1]
Last updated: 10/11/2011


  1. Dugdale DC, Mason JR. Glucose-6-phosphate dehydrogenase deficiency . MedlinePlus. March 2010; Accessed 10/11/2011.
  2. Glucose-6-phosphate dehydrogenase deficiency. Genetics Home Reference (GHR). May 2006; Accessed 10/11/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Glucose-6-phosphate dehydrogenase deficiency. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Glucose-6-phosphate dehydrogenase deficiency. Click on the link to view a sample search on this topic.