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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Glutaric acidemia type II


Other Names for this Disease
  • EMA
  • Ethylmalonic-adipicaciduria
  • GA 2
  • Glutaric acidemia 2
  • Glutaric acidemia type 2
More Names
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Your Question

The child of a good friend has been diagnosed with glutaric acidemia type II. Can this condition be cured at present? If not, what kind of measures should we take to keep the child in good health?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Can glutaric acidemia type II be cured?

Glutaric acidemia type II cannot be cured at this time.[1]
Last updated: 9/20/2011

How might glutaric acidemia type II be treated?

The goal of treatment is to prevent long-term problems. However, children who have repeated metabolic crises may develop life-long learning problems. Individuals with glutaric acidemia type II should consult with a metabolic doctor and a dietician who can help to develop an appropriate dietary plan. Some treatments may be recommended for some children but not for others. When necessary, treatment should be continued throughout the lifetime. The following treatments are often recommended:[1]

    -Avoidance of fasting. Infants and young children with glutaric acidemia type II should eat frequent meals in order to prevent hypoglycemia and metabolic crises.
    -A low-fat, low-protein, high-carbohydrate diet may be advised.
    -Riboflavin, L-carnitine and glycine supplements may be needed. These supplements help the body create energy.
    -Alert the child's doctor if they should become ill, as illness can trigger a metabolic crisis.

Last updated: 8/16/2013

What happens when glutaric acidemia type II is treated?

Although a small number of newborns with symptoms of glutaric acidemia type II have shown benefit from treatment, many babies diagnosed in the newborn period die from heart problems within the first few months of life. Individuals diagnosed later in infancy or childhood have a better outcome. With prompt and careful treatment, many children and adults with this condition live healthy lives with normal growth and development.[1]
Last updated: 9/20/2011

References