Print friendly version
Other Names for this Disease
- Cystic angiomatosis of bone diffuse
- Gorham-Stout disease
- Gorham-Stout syndrome
- Osteolysis massive
- Vanishing bone disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
 It may affect any part of the skeleton, but most commonly involves the skull, shoulder, and pelvic girdle. The cause of Gorham's disease is currently unknown. No familial predisposition has been found. Because of the rarity of this disease, there is not standard therapy available. The main methods of treatment are surgery and radiation therapy. In some cases, Gorham's disease has improved without treatment (spontaneous remission).Gorham's disease is a rare bone disorder that is characterized by bone loss (osteolysis) often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones.
Last updated: 10/6/2011
- Gorham's disease. National Organization for Rare Disorders (NORD). 2005; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/832/viewAbstract. Accessed 10/6/2011.
- Gondivkar SM, Gadbail AR. Gorham-Stout syndrome: a rare clinical entity and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109(2):e41-48. http://www.ncbi.nlm.nih.gov/pubmed/19969488. Accessed 10/6/2011.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
In Depth Information
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Gorham's disease. Click on the link to go to OMIM and review these resources.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Gorham's disease. Click on the link to view a sample search on this topic.
Selected Full-Text Journal Articles
- Patel, Dipak, et.al. Gorham's Disease or Massive Osteolysis. Clinical Medicine & Research. 2005: Volume 3, Number 2:65-74.